Triethylene glycol monodecyl ether

Names

[ Name ]:
Triethylene glycol monodecyl ether

[Synonym ]:
Decyltriglycol
Triethylene glycol monodecyl ether
triethylene glycol monodecyl ether
Emulgin BL 309
C10E3
3,6,9-trioxa-1-nonadecanol
n-decyl triethylene glycol monoether
Triethyleneglycol monodecyl ether solution
triethylene glycol mono-n-decyl ether
Decyl triethylene glycol ether
Triethyleneglycol monodecyl ether 1 mM solution

Biological Activity

[Description]:

Triethylene glycol monodecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
0.936 g/mL at 20ºC(lit.)

[ Molecular Formula ]:
C₁₆H₃₄O₄

[ Molecular Weight ]:
290.43900

[ Exact Mass ]:
290.24600

[ PSA ]:
47.92000

[ LogP ]:
3.16920

[ Index of Refraction ]:
n20/D 1.449

[ Storage condition ]:
2-8°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

The action of alcohols and other non-ionic surface active substances on the sodium current of the squid giant axon.

J. Physiol. 341 , 411, (1983)

The effects of several n-alkanols and n-alkyl oxyethylene alcohols, methyl octanoate, glycerol 1-monooctanoate and dioctanoyl phosphatidylcholine on the ionic currents and electrical capacity of the s...

The effect of surfactants upon rat peritoneal mast cells in vitro.

Food Chem. Toxicol. 14 , 425, (1976)