AM0210000 [RTECS]
Names
[ CAS No. ]:
459-22-3
[ Name ]:
AM0210000 [RTECS]
[Synonym ]:
4-Fluorobenzeneacetonitrile
Benzeneacetonitrile, 4-fluoro-
4-Fluorobenzyl
4-Fluorophenylacetonitrile
Acetonitrile, (p-fluorophenyl)-
PARA-FLUOROBENZYL CYANIDE
p-Fluorobenzyl cyanide
2-(4-Fluorophenyl)acetonitrile
(p-Fluorophenyl)acetonitrile
4-FLUOROBENZYLNITRILE
MFCD00001917
p-Fluorobenzyl nitrile
4-Fluorobenzyl cyanide
4-Fluoroacetonitrile
(4-Fluorophenyl)acetonitrile
AM0210000 [RTECS]
EINECS 207-286-8
4-fluorobenzylacetonitrile
p-Fluorophenylacetonitrile
NC1R DF
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
234.2±0.0 °C at 760 mmHg
[ Melting Point ]:
86ºC
[ Molecular Formula ]:
C8H6FN
[ Molecular Weight ]:
135.138
[ Flash Point ]:
108.3±0.0 °C
[ Exact Mass ]:
135.048431
[ PSA ]:
23.79000
[ LogP ]:
1.50
[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.508
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AM0210000
- CHEMICAL NAME :
- Acetonitrile, (p-fluorophenyl)-
- CAS REGISTRY NUMBER :
- 459-22-3
- BEILSTEIN REFERENCE NO. :
- 1907764
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C8-H6-F-N
- MOLECULAR WEIGHT :
- 135.15
- WISWESSER LINE NOTATION :
- NC1R DF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 42 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07881
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S26-S36-S24/25-S26/36/37/39
[ RIDADR ]:
UN 3276 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
AM0210000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2926909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2926909090
[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Mar. Biotechnol. 15(1) , 97-103, (2013)
Marine fungi belonging to the genera Aspergillus, Penicillium, Cladosporium, and Bionectria catalyzed the biotransformation of phenylacetonitrile to 2-hydroxyphenylacetic acid. Eight marine fungi, sel...
Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents.Bioorg. Med. Chem. 19(18) , 5628-5638, (2011)
We synthesized and evaluated inhibitory activity against T-type Ca(2+) channels for a series of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives. Structure-activity rela...