AM0210000 [RTECS]

Names

[ CAS No. ]:
459-22-3

[ Name ]:
AM0210000 [RTECS]

[Synonym ]:
4-Fluorobenzeneacetonitrile
Benzeneacetonitrile, 4-fluoro-
4-Fluorobenzyl
4-Fluorophenylacetonitrile
Acetonitrile, (p-fluorophenyl)-
PARA-FLUOROBENZYL CYANIDE
p-Fluorobenzyl cyanide
2-(4-Fluorophenyl)acetonitrile
(p-Fluorophenyl)acetonitrile
4-FLUOROBENZYLNITRILE
MFCD00001917
p-Fluorobenzyl nitrile
4-Fluorobenzyl cyanide
4-Fluoroacetonitrile
(4-Fluorophenyl)acetonitrile
AM0210000 [RTECS]
EINECS 207-286-8
4-fluorobenzylacetonitrile
p-Fluorophenylacetonitrile
NC1R DF

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
234.2±0.0 °C at 760 mmHg

[ Melting Point ]:
86ºC

[ Molecular Formula ]:
C₈H₆FN

[ Molecular Weight ]:
135.138

[ Flash Point ]:
108.3±0.0 °C

[ Exact Mass ]:
135.048431

[ PSA ]:
23.79000

[ LogP ]:
1.50

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.508

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM0210000

CHEMICAL NAME :: Acetonitrile, (p-fluorophenyl)-

CAS REGISTRY NUMBER :: 459-22-3

BEILSTEIN REFERENCE NO. :: 1907764

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H6-F-N

MOLECULAR WEIGHT :: 135.15

WISWESSER LINE NOTATION :: NC1R DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07881

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S26-S36-S24/25-S26/36/37/39

[ RIDADR ]:
UN 3276 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
AM0210000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Biotransformation of phenylacetonitrile to 2-hydroxyphenylacetic acid by marine fungi.

Mar. Biotechnol. 15(1) , 97-103, (2013)

Marine fungi belonging to the genera Aspergillus, Penicillium, Cladosporium, and Bionectria catalyzed the biotransformation of phenylacetonitrile to 2-hydroxyphenylacetic acid. Eight marine fungi, sel...

Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents.

Bioorg. Med. Chem. 19(18) , 5628-5638, (2011)

We synthesized and evaluated inhibitory activity against T-type Ca(2+) channels for a series of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives. Structure-activity rela...