3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one

Names

[ Name ]:
3-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one

[Synonym ]:
5-amino-3-(2-deoxypentofuranosyl)-2,3-dihydro-7h-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
8-aza-2'-deoxy-guanosine

Biological Activity

[Description]:

8-Aza-2’-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.29g/cm3

[ Boiling Point ]:
521.7ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₁₂N₆O₄

[ Molecular Weight ]:
268.23

[ Flash Point ]:
269.3ºC

[ Exact Mass ]:
268.09200

[ PSA ]:
152.17000

[ Index of Refraction ]:
2

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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