IR415

Names

[ Name ]:
IR415

[Synonym ]:
MFCD00238878

Biological Activity

[Description]:

IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression, reverses the inhibitory effect of HBx protein on activity of the Dicer endoribonuclease; exhibits a marked depletion of HBV core protein synthesis and down-regulation of pre-genomic HBV RNA in HBV-infected HepG2 cells, selectively targets HBx in a concentration-dependent manner.

[References]

References 1. Ghosh S, et al. J Biol Chem. 2017 Jul 28;292(30):12577-12588. View Related Products by Target HBV

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₄F₂N₄S

[ Molecular Weight ]:
296.34

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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