3-(2-Fluorophenyl)acrylic acid
Names
[ CAS No. ]:
451-69-4
[ Name ]:
3-(2-Fluorophenyl)acrylic acid
[Synonym ]:
3-(2-fluorophenyl)-2-propenoic acid
2-Propenoic acid, 3-(2-fluorophenyl)-, (2E)-
3-(2-Fluorophenyl)acrylic acid
(2E)-3-(2-Fluorophenyl)acrylic acid
2-fluoro-cinnamic acid
(2E)-3-(2-fluorophenyl)prop-2-enoic acid
3-(2-fluoro-phenyl)acrylic acid
TRANS-2-FLUOROCINNAMIC ACID
2-Fluor-zimtsaeure
MFCD00004370
EINECS 207-195-3
2-Fluorocinnamic acid
RARECHEM BK HC T305
o-fluoro-cinnamicaci
2-Fluorociamic acid
Cinnamic acid,o-fluoro
2-fluorincinnamic acid
O-FLUOROCINNAMIC ACID
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
281.6±15.0 °C at 760 mmHg
[ Melting Point ]:
178-180 °C(lit.)
[ Molecular Formula ]:
C9H7FO2
[ Molecular Weight ]:
166.149
[ Flash Point ]:
124.1±20.4 °C
[ Exact Mass ]:
166.043015
[ PSA ]:
37.30000
[ LogP ]:
2.47
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.591
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GD9081000
- CHEMICAL NAME :
- Cinnamic acid, o-fluoro-
- CAS REGISTRY NUMBER :
- 451-69-4
- BEILSTEIN REFERENCE NO. :
- 1863963
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C9-H7-F-O2
- MOLECULAR WEIGHT :
- 166.16
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 5,285,1953
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S37/39-S26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
GD9081000
[ HS Code ]:
2916399090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2916399090
[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Bioorg. Med. Chem. Lett. 15(2) , 363-6, (2005)
Replacement of the morpholinyl moiety in (S,E)-N-[1-(3-morpholinophenyl)ethyl]-3-phenylacrylamide (1) with heteroaryl groups led to the identification of (S,E)-N-1-[3-(6-fluoropyridin-3-yl)phenyl]ethy...