2-Phenylacetophenone

Names

[ CAS No. ]:
451-40-1

[ Name ]:
2-Phenylacetophenone

[Synonym ]:
Ethanone, 1,2-diphenyl-
Benzoin,deoxy
1,2-Diphenylethanone
MFCD00003081
benzyl phenyl ketone
1,2-diphenyl-ethanone
DESOXYBENZOIN
EINECS 207-193-2
Deoxybenzoin
Desoxybenzoine

Biological Activity

[Description]:

2-Phenylacetophenone has broad-spectrum efflux pump inhibition activity. 2-Phenylacetophenone is a benzoin derivative used as a photoinitiator in vinyl polymerization[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vitro]

2-Phenylacetophenone displays antibacterial activity against B. subtilis, M. smegmatis, and M. aurum with MICs of 500 µg/mL[1]. 2-Phenylacetophenone (1000 µg/mL) inhibits biofilm formation for M. smegmatis[1].

[References]

[1]. Hellewell L, et al. Chalcones, stilbenes and ketones have anti-infective properties via inhibition of bacterial drug-efflux and consequential synergism with antimicrobial agents. Access Microbiol. 2020 Feb 18;2(4):acmi000105.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
320.6±11.0 °C at 760 mmHg

[ Melting Point ]:
54-55 °C(lit.)

[ Molecular Formula ]:
C₁₄H₁₂O

[ Molecular Weight ]:
196.245

[ Flash Point ]:
137.0±14.2 °C

[ Exact Mass ]:
196.088821

[ PSA ]:
17.07000

[ LogP ]:
3.18

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.584

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
methanol: 0.1 g/mL, clear

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM9662500

CHEMICAL NAME :: Acetophenone, 2-phenyl-

CAS REGISTRY NUMBER :: 451-40-1

BEILSTEIN REFERENCE NO. :: 1072876

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H12-O

MOLECULAR WEIGHT :: 196.26

WISWESSER LINE NOTATION :: RV1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03836

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AM9662500

[ HS Code ]:
29143900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Polycaprolactone/oligomer compound scaffolds for cardiac tissue engineering.

J. Biomed. Mater. Res. A 102(10) , 3713-25, (2014)

Polycaprolactone (PCL), a synthetic biocompatible and biodegradable polymer generally used as a scaffold material for tissue engineering applications. The high stiffness and hydrophobicity of the PCL ...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.