2-Bromo-5-nitropyridine

Names

[ Name ]:
2-Bromo-5-nitropyridine

[Synonym ]:
2-bromo-5-(nitro)pyridine
5-nitro-2-bromopyridine
MFCD00006222
Pyridine, 2-bromo-5-nitro-
2-brom-5-nitropyridin
2-Bromo-5-nitropyridine
3-Nitro-6-bromopyridine
2-bromo-5-nitroypyridine
2-Bromo-5-Nitro pyridine
EINECS 224-777-2

Biological Activity

[Description]:

2-Bromo-5-nitropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

2-Bromo-5-nitropyridine 用于通过微波介导的 Suzuki-Miyaura 与 (boc-piperazin-1-ylmethyl) 苯基硼酸频哪醇酯偶联来制备 boc 保护的 (piperazin-1-ylmethyl) 联芳基化合物。它还用于合成 2-吡啶基类似物。取代的 5-硝基-2-乙基吡啶是通过 2-溴-5-5-硝基吡啶与末端乙炔的 Sonogashira 反应合成的。

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
289.3±0.0 °C at 760 mmHg

[ Melting Point ]:
139-141 °C(lit.)

[ Molecular Formula ]:
C₅H₃BrN₂O₂

[ Molecular Weight ]:
202.99

[ Flash Point ]:
122.2±21.8 °C

[ Exact Mass ]:
201.937775

[ PSA ]:
58.71000

[ LogP ]:
1.20

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.614

[ Storage condition ]:
Keep Cold

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;Xi: Irritant;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S22

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis of a (piperazin-1-ylmethyl) biaryl library via microwave-mediated Suzuki-Miyaura cross-couplings. Spencer J, et al.

Tetrahedron Lett. 52(31) , 3963-68, (2011)

Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors.

Bioorg. Med. Chem. Lett. 21(19) , 5812-7, (2011)

The diacylglycerol acyltransferase enzyme, DGAT1, presents itself as a potential target for obesity as this enzyme is dedicated to the final committed step in triglyceride biosynthesis. Biphenyl ureas...