Lepadin E

Names

[ CAS No. ]:
444914-19-6

[ Name ]:
Lepadin E

Biological Activity

[Description]:

Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> MDM-2/p53
Signaling Pathways >> Apoptosis >> Ferroptosis

[In Vivo]

Lepadin E

[References]

[1]. Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H47NO3

[ Molecular Weight ]:
421.66

Related Compounds

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