Desmethylnortriptyline

Names

[ Name ]:
Desmethylnortriptyline

[Synonym ]:
Desmethylnortriptyline
N-desmethyl-nortriptyline
didesmethylamitriptyline
5-<3-Amino-propyliden>-10,11-dihydro-5H-dibenzo<a,d>cyclohepten

Biological Activity

[Description]:

Desmethylnortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Burch JE, et al. Determination of desmethyl nortriptyline in plasma by gas chromatography before and after treatment with salicylaldehyde. J Chromatogr. 1983 May 13;274:350-4.

[2]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.

Chemical & Physical Properties

[ Density]:
1.127g/cm3

[ Boiling Point ]:
399.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₉N

[ Molecular Weight ]:
249.35000

[ Flash Point ]:
191.8ºC

[ Exact Mass ]:
249.15200

[ PSA ]:
26.02000

[ LogP ]:
4.26600

[ Index of Refraction ]:
1.664

Safety Information

[ HS Code ]:
2921499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%