Cc-3060

Names

[ Name ]:
Cc-3060

Biological Activity

[Description]:

CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation. CC-3060 degrades ZBTB16 with a DC50 of 0.47 nM in HT-1080 cells. CC-3060 targets ZBTB16 for degradation by primarily engaging distinct structural degrons on different zinc finger domains[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

DC50: 0.47 nM (ZBTB16 in HT-1080 cells)[1]

[References]

[1]. Matyskiela ME, et al. Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons. ACS Chem Biol. 2020 Dec 18;15(12):3149-3158.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₇N₃O₅

[ Molecular Weight ]:
403.39

Related Compounds

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