AG-205

Names

[ Name ]:
AG-205

[Synonym ]:
ag-205

Biological Activity

[Description]:

(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[References]

[1]. Cahill MA. Unde venisti PGRMC? Grand-Scale Biology from Early Eukaryotes and Eumetazoan Animal Origins. Front Biosci (Landmark Ed). 2022 Nov 30;27(11):317

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₃ClN₆OS

[ Molecular Weight ]:
454.97600

[ Exact Mass ]:
454.13400

[ PSA ]:
92.45000

[ LogP ]:
3.55360

Related Compounds

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