Besifovir Dipivoxil maleate

Names

[ Name ]:
Besifovir Dipivoxil maleate

[Synonym ]:
({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methylphosphonic acid dipivoxyl
2,2-Dimethyl-propionic acid [1-(2-amino-purin-9-ylmethyl)-cyclopropoxymethyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester
3-[({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]-8,8-dimethyl-3,7-dioxo-2,4,6-trioxa-3λ5-phosphanon-1-yl-pivalate
9-[1-(phosphonomethoxycyclopropyl)methyl]-6-deoxyguanine
3-[({1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl}oxy)methyl]-8,8-dimethyl-3,7-dioxo-2,4,6-trioxa-3λ5-phosphanon-1-yl pivalate

Biological Activity

[Description]:

Besifovir Dipivoxil maleate (LB80380 maleate) is an oral prodrug of LB80317. Besifovir Dipivoxil maleate (LB80380 maleate) is effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic hepatitis B (CHB) patients in preliminary studies[1][2]

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

[References]

[1]. Yuen MF, et al. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83.

[2]. Lai CL, et al. Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. Gut. 2014 Jun;63(6):996-1004.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₈N₅O₁₂P

[ Molecular Weight ]:
527.50800

[ Exact Mass ]:
527.21400

[ PSA ]:
176.79000

[ LogP ]:
3.81630

Related Compounds

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