Talaglumetad hydrochloride

Names

[ Name ]:
Talaglumetad hydrochloride

[Synonym ]:
Talaglumetad hydrochloride (USAN)
Talaglumetad hydrochloride
Bicyclo(310)hexane-2,6-dicarboxylic acid,2-(((2S)-2-amino-1-oxopropyl)amino)-,monohydrochloride,(1S,2S,5R,6S)
Talaglumetad HCl

Biological Activity

[Description]:

Talaglumetad hydrochloride is a prodrug of thetype II metabotropic glutamate receptor (mGluR2/3) agonist Eglumegad for the treatment of anxiety.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[References]

[1]. Kellner M, Muhtz C, Stark K, Yassouridis A, Arlt J, Wiedemann K. Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results. Psychopharmacology (Berl). 2005;179(1):310-315.

[2]. Varma MV, Eriksson AH, Sawada G, Pak YA, Perkins EJ, Zimmerman CL. Transepithelial transport of the group II metabotropic glutamate 2/3 receptor agonist (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and its prodrug (1S,2S,5R,6S)-2-[(2'S)-(2'-amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344). Drug Metab Dispos. 2009;37(1):211-220.

[3]. Rorick-Kehn LM, Perkins EJ, Knitowski KM, et al. Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344. J Pharmacol Exp Ther. 2006;316(2):905-913.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₇ClN₂O₅

[ Molecular Weight ]:
292.71600

[ Exact Mass ]:
292.08300

[ PSA ]:
133.21000

[ LogP ]:
1.35640

Related Compounds

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