<Suppliers Price>

LNK754

Names

[ CAS No. ]:
439153-64-7

[ Name ]:
LNK754

[Synonym ]:
(2R,3R)-2,3-Dihydroxysuccinic acid - 6-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-ethynylphenyl)-1-methyl-2(1H)-quinolinone (1:1)
Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-ethynylphenyl)-1-methyl-2(1H)-quinolinone (1:1)

Biological Activity

[Description]:

LNK754 is a farnesyltransferase inhibitor, used for the treatment of cancer and Alzheimer's disease.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase
Research Areas >> Cancer
Research Areas >> Neurological Disease

[In Vivo]

LNK-754 (0.9 mg/kg) significantly reduces α-synuclein plaques in a mouse model of PD, APP(SL), at 6 months of age for 3 months[1].

[References]

[1]. Keith T Gagnon. HD Therapeutics-CHDI Fifth Annual Conference. IDrugs. 2010 Apr;13(4):219-23.


[Related Small Molecules]

Tipifarnib (R115777) | FTI-277 (hydrochloride) | L-778123 (hydrochloride) | Lonafarnib | BMS 214662 | FTI-276 trifluoroacetate salt | Prenyl-IN-1 | RPR107393 free base | YM-53601 free base

Chemical & Physical Properties

[ Molecular Formula ]:
C29H22ClN3O2

[ Molecular Weight ]:
479.96

[ Storage condition ]:
2-8℃

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.