Vapendavir

Names

[ Name ]:
Vapendavir

[Synonym ]:
3-Ethoxy-6-{2-[1-(6-methylpyridazin-3-yl)piperidin-4-yl]ethoxy}-1,2-benzisoxazole
Vapendavir [INN]
Vapendavir
UNII-Q8LVL5Z68H
3-Ethoxy-6-(2-(1-(6-methylpyridazin-3-yl)piperidin-4-yl)ethoxy)-1,2-benzoxazole

Biological Activity

[Description]:

Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Enterovirus

[Target]

EC50: 0.5-1.4 μM (EV71 strains)[1][2].

[References]

[1]. Tijsma A, et al. The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. Antimicrob Agents Chemother. 2014 Nov;58(11):6990-2.

[2]. Sun L, et al. Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68. Antimicrob Agents Chemother. 2015 Dec;59(12):7782-5.

Chemical & Physical Properties

[ Density]:
1.191±0.06 g/cm3(Predicted)

[ Boiling Point ]:
612.0±55.0 °C(Predicted)

[ Molecular Formula ]:
C₂₁H₂₆N₄O₃

[ Molecular Weight ]:
382.45600

[ Exact Mass ]:
382.20000

[ PSA ]:
73.51000

[ LogP ]:
4.07540

Related Compounds

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