Curine

Names

[ CAS No. ]:
436-05-5

[ Name ]:
Curine

[Synonym ]:
Chondodendrine
1-Curine
l-Curine
Einecs 207-109-4
(1β)-6,6'-Dimethoxy-2,2'-dimethyltubocuraran-7',12'-diol
(-)-BEBEERINE
1-Bebeerine
Chonodoendrine (L)
L-BEBEERINE
d-bebeerine
(+-)-chondrodendrine

Biological Activity

[Description]:

(-)-Curine is an orally active bisbenzylisoquinoline alkaloid isolated from Chondrodendron platyphyllum. (-)-Curine presents anti-inflammatory and analgesic effects at nontoxic doses, at least in part, resulting from the inhibition of prostaglandin E2 production[1].

[Related Catalog]:

Research Areas >> Endocrinology

[Target]

EP2

[References]

[1]. Leite FC, et al. Curine, an alkaloid isolated from Chondrodendron platyphyllum inhibits prostaglandin E2 in experimental models of inflammation and pain. Planta Med. 2014 Aug;80(13):1072-8.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
706.5±60.0 °C at 760 mmHg

[ Melting Point ]:
213°; mp 221° in vacuo; mp 161°

[ Molecular Formula ]:
C₃₆H₃₈N₂O₆

[ Molecular Weight ]:
594.697

[ Flash Point ]:
381.1±32.9 °C

[ Exact Mass ]:
594.273010

[ PSA ]:
83.86000

[ LogP ]:
4.12

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.620

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R26/27/28

[ Safety Phrases ]:
22-36/37/39-45

[ RIDADR ]:
UN 1544

[ WGK Germany ]:
3

Curine

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Precursor & DownStream

Precursor

DownStream

Related Compounds