Toddaculine

Names

[ Name ]:
Toddaculine

[Synonym ]:
Toddaculin

Biological Activity

[Description]:

Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

[In Vitro]

Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1]. Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1].

[References]

[1]. Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46.

[2]. Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158.

[3]. Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137.

Chemical & Physical Properties

[ Density]:
1.138g/cm3

[ Boiling Point ]:
432.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₈O₄

[ Molecular Weight ]:
274.31200

[ Flash Point ]:
192.2ºC

[ Exact Mass ]:
274.12100

[ PSA ]:
48.67000

[ LogP ]:
3.31890

[ Index of Refraction ]:
1.547

[ Storage condition ]:
2-8℃

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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