4335-12-0

4335-12-0 structure

Name: Toddaculine
Chemical Name: 5,7-dimethoxy-6-(3-methylbut-2-enyl)chromen-2-one
CAS Number: 4335-12-0
Molecular Formula: C₁₆H₁₈O₄
Molecular Weight: 274.31200
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-04-03 04:54:04
Modify Date: 2024-01-02 17:58:56
Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].

Name	5,7-dimethoxy-6-(3-methylbut-2-enyl)chromen-2-one
Synonyms	Toddaculin

Description	Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis
In Vitro	Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1]. Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1].
References	[1]. Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46. [2]. Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158. [3]. Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137.