Z-Phe-Leu

Names

[ Name ]:
Z-Phe-Leu

[Synonym ]:
Cbz-L-Phe-L-Leu-OH
Z-Phe-Leu
N-CBZ-Phe-Leu
N-Benzyloxycarbonyl-L-phenylalanyl-L-leucin
Z-Phe-Leu-OH
Cbz-Phe-Leu-OH

Biological Activity

[Description]:

Z-Phe-Leu-OH (NSC 334018) is a substrate for carboxypeptidase Y (CPY). Z-Phe-Leu-OH is incubated with recombinant CPY to determine peptidase activity[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Makino M, et, al. Carboxypeptidase Y activity and maintenance is modulated by a large helical structure. FEBS Open Bio. 2019 Jul;9(7):1337-1343.

Chemical & Physical Properties

[ Density]:
1.193g/cm3

[ Boiling Point ]:
674.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₃H₂₈N₂O₅

[ Molecular Weight ]:
412.47900

[ Flash Point ]:
361.7ºC

[ Exact Mass ]:
412.20000

[ PSA ]:
104.73000

[ LogP ]:
3.92140

[ Index of Refraction ]:
1.564

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream

Articles

Amphipathic property of free thiol group contributes to an increase in the catalytic efficiency of carboxypeptidase Y.

Eur. J. Biochem. 269 , 3220-3225, (2002)

Cys341 of carboxypeptidase Y, which constitutes one side of the solvent-accessible surface of the S1 binding pocket, was replaced with Gly, Ser, Asp, Val, Phe or His by site-directed mutagenesis. Kine...

Debittering effect of Actinomucor elegans peptidases on soybean protein hydrolysates.

J. Ind. Microbiol. Biotechnol. 35 , 41-47, (2008)

Effects of the enzymes in Actinomucor elegans extract and the enzyme Alcalase 2.4L on debittering the soybean protein hydrolysates were investigated. When the protein was treated only with the latter,...

Characterization of a bifunctional aminoacylase/carboxypeptidase from radioresistant bacterium Deinococcus radiodurans R1.

J. Biotechnol. 128 , 322-334, (2007)

The gene encoding a Deinococcus radiodurans R1 bifunctional aminoacylase/carboxypeptidase (DR_ACY/CP) was amplified by polymerase chain reaction and cloned into pQE-30 to generate pQE-DRAC. The cloned...

Related Compounds

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