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Cathepsin G Inhibitor I

Names

[ CAS No. ]:
429676-93-7

[ Name ]:
Cathepsin G Inhibitor I

[Synonym ]:
Phosphonic acid, [2-[3-[[(1-benzoyl-4-piperidinyl)methylamino]carbonyl]-2-naphthalenyl]-1-(1-naphthalenyl)-2-oxoethyl]-
Cathepsin G Inhibitor I
[2-{3-[(1-benzoylpiperidin-4-yl)(methyl)carbamoyl]naphthalen-2-yl}-1-(naphthalen-1-yl)-2-oxoethyl]phosphonic acid
[2-{3-[(1-Benzoyl-4-piperidinyl)(methyl)carbamoyl]-2-naphthyl}-1-(1-naphthyl)-2-oxoethyl]phosphonic acid

Biological Activity

[Description]:

Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[References]

[1]. Greco MN, et al. Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design. J Am Chem Soc. 2002 Apr 17;124(15):3810-1.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
912.0±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C36H33N2O6P

[ Molecular Weight ]:
620.631

[ Flash Point ]:
505.4±37.1 °C

[ Exact Mass ]:
620.207642

[ PSA ]:
125.03000

[ LogP ]:
2.01

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.713

Safety Information

[ Hazard Codes ]:
Xi


Related Compounds