7-Hydroxymethyl-10,11-MDCPT

Names

[ CAS No. ]:
428816-69-7

[ Name ]:
7-Hydroxymethyl-10,11-MDCPT

Biological Activity

[Description]:

7-Hydroxymethyl-10,11-MDCPT is an analog of camptothecin. 7-Hydroxymethyl-10,11-MDCPT inhibits tumor cell line growth with IC50s of 230.9, 90.8, 404.5 nM against HeLa-S3, PC-3, and HT-29, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Wadkins RM, et al. Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I. Cancer Res. 2004 Sep 15;64(18):6679-83.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H18N2O7

[ Molecular Weight ]:
422.39

Related Compounds

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