Benzyl-PEG7-alcohol

Names

[ Name ]:
Benzyl-PEG7-alcohol

[Synonym ]:
1-Phenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-ol
monobenzyl heptaethylene glycol
Heptaethylene glycol Monobenzyl ether
Benzyl-PEG7-alcohol

Biological Activity

[Description]:

Benzyl-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.099±0.06 g/cm3

[ Boiling Point ]:
508.4±45.0 °C

[ Molecular Formula ]:
C₂₁H₃₆O₈

[ Molecular Weight ]:
416.50600

[ Exact Mass ]:
416.24100

[ PSA ]:
84.84000

[ LogP ]:
1.29510

Safety Information

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Related Compounds

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