Methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
297.7±40.0 °C at 760 mmHg

[ Melting Point ]:
69-71ºC(lit.)

[ Molecular Formula ]:
C₁₁H₁₂O₄

[ Molecular Weight ]:
208.211

[ Flash Point ]:
129.2±27.4 °C

[ Exact Mass ]:
208.073563

[ PSA ]:
48.06000

[ LogP ]:
1.27

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.534

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Click to get detail synthetic route

Precursor

DownStream

Optimization of Serratia marcescens lipase production for enantioselective hydrolysis of 3-phenylglycidic acid ester.

J. Ind. Microbiol. Biotechnol. 31(11) , 525-30, (2004)

Lipase production and cell growth of Serratia marcescens ECU1010 were optimized in shake flasks, with lipase production being enhanced 9.5-fold (4,780 U/l) compared with the initial activity (500 U/l)...

A practical procedure for the large-scale preparation of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate, a key intermediate for diltiazem.

J. Org. Chem. 67(13) , 4599-601, (2002)

A practical synthesis of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate (-)-2, a key intermediate for diltiazem (1), was developed. Treatment of methyl (E)-4-methoxycinnamate 3 with chiral dioxirane, gen...

Highly enantioselective mukaiyama aldol reaction of alpha,alpha-dichloro ketene silyl acetal: an efficient synthesis of a key intermediate for diltiazem.

J. Org. Chem. 68(3) , 974-9, (2003)

An efficient synthesis of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate (-)-2, a key intermediate for diltiazem (1), has been developed on the basis of the highly enantioselective Mukaiyama aldol reacti...

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