SW-083688
Names
[ CAS No. ]:
422281-45-6
[ Name ]:
SW-083688
Biological Activity
[Description]:
SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM; increases the abundance of p62 and inhibits autophagy; TAOK2 is an activator of p38 MAP kinase cascade that is up-regulated in response to environmental stresses, and a potential cancer therapeutic target.
[References]
References 1. Piala AT, et al. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3923-7. View Related Products by Target MEKK (MAP3K)
Chemical & Physical Properties
[ Molecular Formula ]:
C23H25N3O5S
[ Molecular Weight ]:
455.529