SW IV-134
Names
[ CAS No. ]:
1613383-99-5
[ Name ]:
SW IV-134
Biological Activity
[Description]:
SW IV-134 is a sigma-2/SMAC drug conjugate, chemically linked the sigma-2 ligand SW43 to the Smac mimetic SW IV-52.SW IV-134 slowed tumor growth and improved survival in murine models of pancreatic cancer.SW IV-134 significantly reduced tumor burden and improved overall survival in a mouse xenograft model of ovarian cancer without causing significant adverse effects to normal tissues.SW IV-134 induced degradation of cIAP-1 and cIAP-2 leading to NF-қB activation and TNFα-dependent cell death.
[References]
1. Garg G, et al. Mol Cancer. 2014 Mar 7;13:50. 2. Hashim YM, et al. Mol Oncol. 2014 Jul;8(5):956-67. 3. Hashim YM, et al. J Exp Clin Cancer Res. 2017 Jan 17;36(1):14. 4. Oost TK, et al. J Med Chem. 2004;47:4417–4426.
Chemical & Physical Properties
[ Molecular Formula ]:
C51H78N6O6
[ Molecular Weight ]:
871.221