Tolonidine

Names

[ Name ]:
Tolonidine

[Synonym ]:
Tolonidina
Tolonidinum
ST-375
Tolonidine
Euctan

Biological Activity

[Description]:

Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vivo]

In the anesthetized dog, tolonidine administered i.v. decreases the amplitude of ventricular contractions, reduces aortic blood flow and increases peripheral vascular resistances[1]. In the bivagotomized pithed rat, tolonidine induces a long-lasting increase in blood pressure with no secondary hypotension, thus suggesting peripheral sympathomimetic properties[1].

[References]

[1]. Cosnier D, et al. Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis. Arzneimittelforschung. 1975 Nov;25(11):1802-6.

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
314ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂ClN₃

[ Molecular Weight ]:
209.67500

[ Flash Point ]:
143.7ºC

[ Exact Mass ]:
209.07200

[ PSA ]:
36.42000

[ LogP ]:
1.85690

[ Index of Refraction ]:
1.637

Safety Information

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%