4201-22-3
4201-22-3 structure
- Name: Tolonidine
- Chemical Name: N-(2-chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine
- CAS Number: 4201-22-3
- Molecular Formula: C10H12ClN3
- Molecular Weight: 209.67500
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-02-15 08:00:00
- Modify Date: 2025-08-25 17:27:57
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Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties[1].
| Name | N-(2-chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine |
|---|---|
| Synonyms |
Tolonidina
Tolonidinum ST-375 Tolonidine Euctan |
| Description | Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties[1]. |
|---|---|
| Related Catalog | |
| In Vivo | In the anesthetized dog, tolonidine administered i.v. decreases the amplitude of ventricular contractions, reduces aortic blood flow and increases peripheral vascular resistances[1]. In the bivagotomized pithed rat, tolonidine induces a long-lasting increase in blood pressure with no secondary hypotension, thus suggesting peripheral sympathomimetic properties[1]. |
| References |
| Density | 1.31g/cm3 |
|---|---|
| Boiling Point | 314ºC at 760 mmHg |
| Molecular Formula | C10H12ClN3 |
| Molecular Weight | 209.67500 |
| Flash Point | 143.7ºC |
| Exact Mass | 209.07200 |
| PSA | 36.42000 |
| LogP | 1.85690 |
| Index of Refraction | 1.637 |
| HS Code | 2933290090 |
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| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |