COX-2-IN-5

Names

[ CAS No. ]:
416901-58-1

[ Name ]:
COX-2-IN-5

[Synonym ]:
LM-1685
Methyl 1-(4-chlorobenzyl)-5-(methylsulfonyl)-1H-indole-2-carboxylate
1H-Indole-2-carboxylic acid, 1-[(4-chlorophenyl)methyl]-5-(methylsulfonyl)-, methyl ester

Biological Activity

[Description]:

COX-2-IN-5 (compound 11a) is a potent COX-2 inhibitor with an IC50 value of 0.65 µM. COX-2-IN-5 has the potential for the research of inflammation[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2:0.65 μM (IC50)


[References]

[1]. Palomer A, et al. Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem. 2002 Mar 28;45(7):1402-11.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
604.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H16ClNO4S

[ Molecular Weight ]:
377.842

[ Flash Point ]:
319.3±31.5 °C

[ Exact Mass ]:
377.048859

[ LogP ]:
2.73

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.620

Related Compounds