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Resorcinolnaphthalein

Names

[ CAS No. ]:
41307-63-5

[ Name ]:
Resorcinolnaphthalein

[Synonym ]:
Spiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-
3',6'-Dihydroxy-3H-spiro[benzo[de]isochromene-1,9'-xanthen]-3-one
Resorcinolnaphthalin
resorcinalnaphthalein
3',6'-Dihydroxy-spiro[benz[de]isochromen-1,9'-xanthen]-3-on
3',6'-dihydroxyspiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen]-3-one
3',6'-dihydroxy-spiro[benz[de]isochromene-1,9'-xanthen]-3-one

Biological Activity

[Description]:

Resorcinolnaphthalein is a specific angiotensin-converting enzyme 2 (ACE2) enhancer and activates ACE2 activity with an EC50 value of 19.5 μM. Resorcinolnaphthalein can be used for the investigation of hypertension and renal fibrosis[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Research Areas >> Inflammation/Immunology

[Target]

EC50: 19.5 μM (ACE2)[1]


[In Vitro]

Resorcinolnaphthalein (100 μM) and XNT enhances ACE2 activity in a dose-dependent manner with EC50 values of 19.5 μM and 20.1 μM, respectively[1]. ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology[1].

[References]

[1]. Hernández Prada JA, et al.Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.Hypertension. 2008 May;51(5):1312-7.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
688.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H14O5

[ Molecular Weight ]:
382.365

[ Flash Point ]:
249.7±25.0 °C

[ Exact Mass ]:
382.084137

[ PSA ]:
75.99000

[ LogP ]:
4.21

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.830

Synthetic Route

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Precursor & DownStream

Precursor

DownStream