N-Desmethyl Galanthamine

Names

[ Name ]:
N-Desmethyl Galanthamine

[Synonym ]:
N-Norgalanthamine
N-Demethylgalantamine
Norgalantamine
N-desmethyl galantamine
UNII-2BPQ4IVQ21

Biological Activity

[Description]:

N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Bachus R, et al. The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6. Pharmacogenetics. 1999;9(6):661-668.

[2]. Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86.

Chemical & Physical Properties

[ Density]:
1.309g/cm3

[ Boiling Point ]:
457.923ºC at 760 mmHg

[ Melting Point ]:
142-145ºC

[ Molecular Formula ]:
C₁₆H₁₉NO₃

[ Molecular Weight ]:
273.32700

[ Flash Point ]:
230.744ºC

[ Exact Mass ]:
273.13600

[ PSA ]:
50.72000

[ LogP ]:
1.83690

[ Index of Refraction ]:
1.642

Safety Information

[ Hazard Codes ]:
T+

Precursor & DownStream

Precursor

DownStream

Related Compounds

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