Lepadin H

Names

[ CAS No. ]:
412328-25-7

[ Name ]:
Lepadin H

Biological Activity

[Description]:

Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Apoptosis >> Ferroptosis

[References]

[1]. Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H45NO3

[ Molecular Weight ]:
419.64

Related Compounds

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