Inophyllum B

Names

[ Name ]:
Inophyllum B

[Synonym ]:
(10R,11S,12S)-10,11-dihydro-12-hydroxy-4-phenyl-6,6,10,11-tetramethyl-2H,6H,12H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one
(10R,11S,12S)-12-Hydroxy-6,6,10,11-tetramethyl-4-phenyl-11,12-dihydro-6H,10H-dipyrano[2,3-f
2',3'-h]chromen-2-one
inophyllum B
inophyllum-B

Biological Activity

[Description]:

Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC50 value of 38 nM. Inophyllum B inhibits HIV-1 (IC50=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[Target]

HIV-1:1.4 μM (IC50)

Reverse Transcriptase:38 nM (IC50)

[References]

[1]. Patil AD, et al. The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn. J Med Chem. 1993 Dec 24;36(26):4131-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₄O₅

[ Molecular Weight ]:
404.45500

[ Exact Mass ]:
404.16200

[ PSA ]:
68.90000

[ LogP ]:
5.09460

Related Compounds

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