41135-06-2

41135-06-2 structure

Name: Inophyllum B
Chemical Name: (+)-inophyllum B
CAS Number: 41135-06-2
Molecular Formula: C₂₅H₂₄O₅
Molecular Weight: 404.45500
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2018-04-04 21:50:50
Modify Date: 2024-01-10 18:42:33
Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC50 value of 38 nM. Inophyllum B inhibits HIV-1 (IC50=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica[1].

Name	(+)-inophyllum B
Synonyms	(10R,11S,12S)-10,11-dihydro-12-hydroxy-4-phenyl-6,6,10,11-tetramethyl-2H,6H,12H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one (10R,11S,12S)-12-Hydroxy-6,6,10,11-tetramethyl-4-phenyl-11,12-dihydro-6H,10H-dipyrano[2,3-f 2',3'-h]chromen-2-one inophyllum B inophyllum-B

Description	Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC50 value of 38 nM. Inophyllum B inhibits HIV-1 (IC50=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Reverse Transcriptase
Target	HIV-1:1.4 μM (IC50) Reverse Transcriptase:38 nM (IC50)
References	[1]. Patil AD, et al. The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn. J Med Chem. 1993 Dec 24;36(26):4131-8.