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Azido-PEG6-C2-Boc

Names

[ CAS No. ]:
406213-76-1

[ Name ]:
Azido-PEG6-C2-Boc

[Synonym ]:
2-Methyl-2-propanyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate
3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-azido-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

Azido-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C19H37N3O8

[ Molecular Weight ]:
435.512

[ Exact Mass ]:
435.258057

[ LogP ]:
-0.09

[ Storage condition ]:
2-8°C

Related Compounds