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MSX-130

Names

[ CAS No. ]:
4051-59-6

[ Name ]:
MSX-130

[Synonym ]:
2,2'-(1,4-Phenylene)bis(4,5-diphenyl-1H-imidazole)
2,2'-benzene-1,4-diylbis(4,5-diphenyl-1H-imidazole)
1H-Imidazole, 2,2'-(1,4-phenylene)bis[4,5-diphenyl-

Biological Activity

[Description]:

MSX-130 is a CXCR4 antagonist. MSX-130 inhibits cancer metastasis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> CXCR
Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR4


[In Vitro]

The C-X-C chemokine receptor-4 (CXCR4) is a seven trans-membrane G-protein coupled receptor (GPCR) classified as a member of the family I GPCR or rhodopsin-like GPCR family. CXCR4 plays an important role in cancer metastasis, regulation of stem cell trafficking, and neovascularization[1].

[References]

[1]. Zhan W, et al. Discovery of small molecule CXCR4 antagonists. J Med Chem. 2007 Nov 15;50(23):5655-64.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
766.3±48.0 °C at 760 mmHg

[ Molecular Formula ]:
C36H26N4

[ Molecular Weight ]:
514.618

[ Flash Point ]:
326.5±22.5 °C

[ Exact Mass ]:
514.215759

[ LogP ]:
11.84

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.672

Related Compounds