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MSX-127

Names

[ CAS No. ]:
6616-56-4

[ Name ]:
MSX-127

[Synonym ]:
1,4-diacetoxy-2,5-bis-morpholin-4-ylmethyl-benzene
Methyl 1H-benzo[d]iMidazole-2-carboxylate
2,5-bis-morpholin-4-ylmethyl-benzene-1,4-diol
2-(phenoxy)ethanamide
2,5-Bis-morpholinomethyl-hydrochinon-diacetat
2,5-bis-(morpholinomethyl)-hydroquinone
1,4-Benzenediol,2,5-bis(4-MorpholinylMethyl)-,1,4-diacetate
2,5-Bis-<morpholinomethyl>-hydrochinon
MSX-127

Biological Activity

[Description]:

MSX-127 is a CXCR4 antagonist. MSX-127 inhibits cancer metastasis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> CXCR
Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR4


[In Vitro]

The C-X-C chemokine receptor-4 (CXCR4) is a seven trans-membrane G-protein coupled receptor (GPCR) classified as a member of the family I GPCR or rhodopsin-like GPCR family. CXCR4 plays an important role in cancer metastasis, regulation of stem cell trafficking, and neovascularization[1].

[References]

[1]. Zhan W, et al. Discovery of small molecule CXCR4 antagonists. J Med Chem. 2007 Nov 15;50(23):5655-64.

Chemical & Physical Properties

[ Density]:
1.278g/cm3

[ Boiling Point ]:
486.7ºC at 760 mmHg

[ Molecular Formula ]:
C16H24N2O4

[ Molecular Weight ]:
308.37300

[ Flash Point ]:
248.2ºC

[ Exact Mass ]:
308.17400

[ PSA ]:
65.40000

[ LogP ]:
0.63800

[ Index of Refraction ]:
1.605

Related Compounds