9H-Purine, 2-methoxy-9-b-D-ribofuranosyl-

Names

[ Name ]:
9H-Purine, 2-methoxy-9-b-D-ribofuranosyl-

[Synonym ]:
2-(hydroxymethyl)-5-(2-methoxypurin-9-yl)oxolane-3,4-diol

Biological Activity

[Description]:

2-Methoxy-9-β-D-ribofuranosyl-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.84g/cm3

[ Boiling Point ]:
625.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₄N₄O₅

[ Molecular Weight ]:
282.25

[ Flash Point ]:
332.3ºC

[ Exact Mass ]:
282.09600

[ PSA ]:
122.75000

[ Index of Refraction ]:
1.773

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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