5’-Azido-5’-deoxyuridine

Names

[ CAS No. ]:
39483-48-2

[ Name ]:
5’-Azido-5’-deoxyuridine

[Synonym ]:
1-(5-Azido-5-deoxy-β-D-ribofuranosyl)-4-hydroxy-2(1H)-pyrimidinone
2(1H)-Pyrimidinone, 1-(5-azido-5-deoxy-β-D-ribofuranosyl)-4-hydroxy-

Biological Activity

[Description]:

5’-Azido-5’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H11N5O5

[ Molecular Weight ]:
269.21

[ Exact Mass ]:
269.076019

[ LogP ]:
-1.46

Related Compounds

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