5′-Fluoro-2′-hydroxyacetophenone

Names

[ CAS No. ]:
394-32-1

[ Name ]:
5′-Fluoro-2′-hydroxyacetophenone

[Synonym ]:
1-(5-Fluoro-2-hydroxyphenyl)ethanone
5’-Fluoro-2’-hydroxyacetophenone
5‘-Fluoro-2‘-hydroxyacetophenone
MFCD00011668
Acetophenone, 5'-fluoro-2'-hydroxy-
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
1-(5-fluoro-2-hydroxyphenyl)ethan-1-one
EINECS 206-893-5
5'-Fluoro-2'-hydroxyacetophenone
QR DF BV1
5′-Fluoro-2′-hydroxyacetophenone
Ethanone, 1-(5-fluoro-2-hydroxyphenyl)-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
182.2±0.0 °C at 760 mmHg

[ Melting Point ]:
56-58 °C(lit.)

[ Molecular Formula ]:
C₈H₇FO₂

[ Molecular Weight ]:
154.138

[ Flash Point ]:
97.7±21.8 °C

[ Exact Mass ]:
154.043015

[ PSA ]:
37.30000

[ LogP ]:
2.30

[ Vapour Pressure ]:
0.6±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.530

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM8502300

CHEMICAL NAME :: Acetophenone, 5'-fluoro-2'-hydroxy-

CAS REGISTRY NUMBER :: 394-32-1

BEILSTEIN REFERENCE NO. :: 2359087

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H7-F-O2

MOLECULAR WEIGHT :: 154.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 11,137,1964

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AM8502300

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis and anti-rhinovirus properties of fluoro-substituted flavonoids. Conti C, et al.

Antiviral Chem. Chemother. 16(4) , 267-76, (2005)