1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

Names

[ Name ]:
1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

[Synonym ]:
1-(2,4-Dimethylphenyl)-4-(3-methyl-1-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidine
VU0080241
1H-Pyrazolo[3,4-d]pyrimidine, 1-(2,4-dimethylphenyl)-4-(3-methyl-1-piperidinyl)-
MFCD03474901

Biological Activity

[Description]:

VU0080241 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 4 (mGluR4), with an EC50 of 4.6 μM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

mGlu4:4.6 μM (EC50)

[References]

[1]. Colleen M Niswender, et al. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators. Bioorg Med Chem Lett. 2008 Oct 15; 18(20): 5626-5630.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
447.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₃N₅

[ Molecular Weight ]:
321.419

[ Flash Point ]:
224.4±28.7 °C

[ Exact Mass ]:
321.195343

[ LogP ]:
4.41

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.672

Related Compounds

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