Rapamycin-d3

Names

[ Name ]:
Rapamycin-d3

[Synonym ]:
[2H3]-Sirolimus
Rapamycin,7-O-demethyl-7-O-(methyl-d3)

Biological Activity

[Description]:

Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282(18), 13395-13401.

[2]. Rangaraju S, et al. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathicmice. J Neurosci. 2010 Aug 25;30(34):11388-97.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₁H₇₆D₃NO₁₃

[ Molecular Weight ]:
917.19000

[ Exact Mass ]:
916.57400

[ PSA ]:
195.43000

[ LogP ]:
6.11850

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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