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Promestriene

Names

[ CAS No. ]:
39219-28-8

[ Name ]:
Promestriene

[Synonym ]:
17-Methoxy-3-propoxyestra-1,3,5(10)-triene
MFCD00867247
Promestriene
EINECS 254-361-6
Promestriene [DCF:INN]
Estra-1,3,5(10)-triene, 17-methoxy-3-propoxy-
3-Propoxy-17beta-methoxy-1,3,5(10)-estratriene

Biological Activity

[Description]:

Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Endocrinology
Signaling Pathways >> Others >> Others

[In Vitro]

Promestriene is an analogue of oestradiol which is minimally absorbed and devoid of systemic effects when administered intravaginally, either as gynecological cream or capsules[2]. Topical Promestriene is minimally absorbed with chronic use and has been reported to significantly improve the symptoms of vaginal atrophy[3].

[References]

[1]. Isabel Santos, et al. Urogenital Disorders Associated With Oestrogen Deficiency: The Role of Promestriene as Topical Oestrogen Therapy. Gynecol Endocrinol. 2010 Sep;26(9):644-51.

[2]. Lino Del Pup, et al. Promestriene, a Specific Topic Estrogen. Review of 40 Years of Vaginal Atrophy Treatment: Is It Safe Even in Cancer Patients. Anticancer Drugs. 2013 Nov;24(10):989-98.

[3]. AJO Almodovar, et al. Abstract P5-05-07: Promestriene effects on estrogen-sensitive breast cancer cell proliferation in vitro. Cancer Res 2013;73(24 Suppl): Abstract nr P5-05-07.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
436.8±45.0 °C at 760 mmHg

[ Melting Point ]:
64-660ºC

[ Molecular Formula ]:
C22H32O2

[ Molecular Weight ]:
328.488

[ Flash Point ]:
153.3±28.3 °C

[ Exact Mass ]:
328.240234

[ PSA ]:
18.46000

[ LogP ]:
6.48

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.546

[ Storage condition ]:
-20°C Freezer

Related Compounds