N-acryloxysuccinimide

Names

[ Name ]:
N-acryloxysuccinimide

[Synonym ]:
N-SucciniMidyl Acrylate
1-(Acryloyloxy)pyrrolidine-2,5-dione
N-acryloxysuccinimide
N-Acryloyloxysuccinimide
Acrylic Acid N-Succinimidyl Ester
1-(Acryloyloxy)-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[(1-oxo-2-propen-1-yl)oxy]-
2,5-pyrrolidinedione, 1-[(1-oxo-2-propenyl)oxy]-
2,5-Dioxopyrrolidin-1-yl acrylate
MFCD00078261
1-[(1-Oxo-2-propenyl)oxy]-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-((1-oxo-2-propenyl)oxy)-

Biological Activity

[Description]:

2,5-Dioxopyrrolidin-1-yl acrylate (N-Succinimidyl acrylate) is a protein crosslinker. 2,5-Dioxopyrrolidin-1-yl acrylate can react with a monoclonal anti-horseradish peroxidase IgG antibody (anti-HRP) to modify lysine residues[1].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Okyem S, et, al. High-Affinity Points of Interaction on Antibody Allow Synthesis of Stable and Highly Functional Antibody-Gold Nanoparticle Conjugates. Bioconjug Chem. 2021 Aug 18;32(8):1753-1762.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
251.3±23.0 °C at 760 mmHg

[ Melting Point ]:
69 °C

[ Molecular Formula ]:
C₇H₇NO₄

[ Molecular Weight ]:
169.135

[ Flash Point ]:
105.8±22.6 °C

[ Exact Mass ]:
169.037506

[ PSA ]:
63.68000

[ LogP ]:
-1.21

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.520

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R36/37/38;R40;R48/20/22

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

A one-step preparation method of monolithic enzyme reactor for highly efficient sample preparation coupled to mass spectrometry-based proteomics studies.

J. Chromatogr. A. 1412 , 75-81, (2015)

Mass spectrometry (MS) coupled to sample preparation and separation techniques has become a primary tool for proteomics studies. However, due to sample complexity, it is often challenging to achieve f...

Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel.

J. Biosci. Bioeng. 118(4) , 461-8, (2014)

Hydrogel has been used for regenerating myocardial infraction (MI) as a delivery vehicle for cells and growth factors. This study showed that injectable hyaluronic acid (HA)-based hydrogels alone woul...

Effect of sustained release of rhBMP-2 from dried and wet hyaluronic acid hydrogel carriers compared with direct dip coating of rhBMP-2 on peri-implant osteogenesis of dental implants in canine mandibles.

J. Craniomaxillofac. Surg. 44 , 116-25, (2016)

Hyaluronic acid (HA) hydrogel has been used as a carrier of recombinant human bone morphogenetic protein (rhBMP)-2 for sustained delivery. To enhance peri-implant osteogenesis, a dried coating of rhBM...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.