Nicotinamide 1,N6-Ethenoadenine Dinucleotide

Names

[ Name ]:
Nicotinamide 1,N6-Ethenoadenine Dinucleotide

[Synonym ]:
1,N6-ETHENO NAD
Nicotinamide 1,N6-ethenoadenine dinucleotide
Nicotinamide1,N6-EthenoadenineDinucleotide

Biological Activity

[Description]:

Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) , a fluorescent analogue of NAD, is able to serve as a substrate for the bacterial toxincatalyzed G-ADP ribosylation of signal-transducing G-proteins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the studies of the ADP ribosylation reaction[1].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Hingorani VN, et al. Fluorescent labeling of signal-transducing G-proteins. Pertussis toxin-catalyzed etheno-ADP ribosylation of transducin. J Biol Chem. 1988 Dec 25;263(36):19804-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₇N₇O₁₄P₂

[ Molecular Weight ]:
687.44700

[ Exact Mass ]:
687.10900

[ PSA ]:
319.10000

[ Storage condition ]:
20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Hormonal control of ADP-ribosyl cyclase activity in pancreatic acinar cells from rats.

J. Biol. Chem. 278(36) , 33629-36, (2003)

Cyclic ADP-ribose, a metabolite of NAD+ evokes Ca2+ release from intracellular stores in different cells. We have determined the activity of cADPr-producing enzymes (ADP-ribosyl cyclases) in different...

NAD+ analogs substituted in the purine base as substrates for poly(ADP-ribosyl) transferase.

FEBS Lett. 397 , 17-21, (1996)

Poly(ADP-ribosyl) transferase (pADPRT) catalyzes the transfer of the ADP-ribose moiety from NAD+ onto proteins as well as onto protein-bound ADP-ribose. As a result, protein-bound polymers of ADP-ribo...

Assay for ADP-ribosyl cyclase by reverse-phase high-performance liquid chromatography.

Anal. Biochem. 299(2) , 218-26, (2001)

Cyclic ADP-ribose (cADPR), a natural metabolite of beta-NAD(+), is a second messenger for Ca(2+) signaling in T cells. As a tool for purification and identification of ADP-ribosyl cyclase(s) in T cell...

Related Compounds

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