D75-4590

Names

[ Name ]:
D75-4590

[Synonym ]:
1-{[2-(Diethylamino)ethyl]amino}-2-ethyl-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile
D75-4590
MFCD05738885
Pyrido[1,2-a]benzimidazole-4-carbonitrile, 1-[[2-(diethylamino)ethyl]amino]-2-ethyl-3-methyl-

Biological Activity

[Description]:

D75-4590, a pyridobenzimidazole derivative and a β-1,6-glucan synthesis inhibitor, possesses antifungal activity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Inflammation/Immunology

[In Vitro]

D75-4590 has activities against a variety of Candida species, including fluconazole-resistant strains. Most strains of C. albicans, C. tropicalis, and C. parapsilosis displayed trailing growth phenomena similar to those observed in the presence of azoles[1].

[References]

[1]. Akihiro Kitamura, et al. Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. Antimicrob Agents Chemother. 2009 Feb;53(2):670-7.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₂₇N₅

[ Molecular Weight ]:
349.47

[ Exact Mass ]:
349.226654

[ LogP ]:
4.26

[ Index of Refraction ]:
1.607

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.