YE 120

Names

[ Name ]:
YE 120

[Synonym ]:
2-Dicyanmethylen-3-cyan-4,6-dimethyl-1,2-dihydro-pyridin
1,2-Dihydro-2-dicyanmethylen-3-cyan-4,6-dimethylpyridin
3-cyano-2-dicyanomethylene-4,6-dimethyl-1,2-dihydropyridine
Fatostatin A

Biological Activity

[Description]:

YE120 is a potent GPR35 agonist with an EC50 of 32.5 nM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Deng H, et al. Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists. J Med Chem. 2011 Oct 27;54(20):7385-96.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₉Cl₂N₃O

[ Molecular Weight ]:
330.16800

[ Exact Mass ]:
329.01200

[ PSA ]:
80.60000

[ LogP ]:
4.38014

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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