Malonomicin

Names

[ Name ]:
Malonomicin

[Synonym ]:
Malonomicin
2-((S)-2-Amino-3-hydroxy-propionylamino)-2-[2-((S)-5-aminomethyl-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-2-oxo-ethyl]-malonic acid
{[(2S)-2-amino-3-hydroxypropanoyl]amino}{2-[(5S)-5-(aminomethyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2-oxoethyl}malonic acid

Biological Activity

[Description]:

Malonomicin (Antibiotic K16) is an antibiotic with anti-protozoa and anti-trypanosome activities. Malonomicin also shows anti-trypanosome activity in vivo[1][2].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Malonomicin 具有抑制抗刚果锥虫的活性[1]。

[In Vivo]

Malonomicin (30 mg/kg；腹腔注射，一次) 消除锥虫感染小鼠的感染情况，并且在每日 50 mg/kg 的剂量下没有显示出有害影响[2]。 Animal Model: Mice with Trypanosoma congolense infection[2] Dosage: 30 mg/kg Administration: Intraperitoneal injection; 30 mg/kg, once Result: Eliminated all trypanosomes from in the blood of infected mice.

[References]

[1]. Emilio L. Ghisalberti. Bioactive Tetramic Acid Metabolites. Studies in Natural Products Chemistry. Volume 28, Part I, 2003, Pages 109-163.

[2]. Ottens Hendrik and Vos Cornelis. Preparation of an antibiotic for the treatment of trypanosomiasis. NL6701356. 1967.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₈N₄O₉

[ Molecular Weight ]:
374.30300

[ Exact Mass ]:
374.10700

[ PSA ]:
242.37000

Related Compounds

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