38249-71-7

38249-71-7 structure

Name: Malonomicin
Chemical Name: malonomicin
CAS Number: 38249-71-7
Molecular Formula: C₁₃H₁₈N₄O₉
Molecular Weight: 374.30300
Catalog: Research Areas Infection
Create Date: 2018-06-26 05:29:30
Modify Date: 2024-01-02 20:44:05
Malonomicin (Antibiotic K16) is an antibiotic with anti-protozoa and anti-trypanosome activities. Malonomicin also shows anti-trypanosome activity in vivo[1][2].

Name	malonomicin
Synonyms	Malonomicin 2-((S)-2-Amino-3-hydroxy-propionylamino)-2-[2-((S)-5-aminomethyl-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)-2-oxo-ethyl]-malonic acid {[(2S)-2-amino-3-hydroxypropanoyl]amino}{2-[(5S)-5-(aminomethyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2-oxoethyl}malonic acid

Description	Malonomicin (Antibiotic K16) is an antibiotic with anti-protozoa and anti-trypanosome activities. Malonomicin also shows anti-trypanosome activity in vivo[1][2].
Related Catalog	Research Areas >> Infection
In Vitro	Malonomicin 具有抑制抗刚果锥虫的活性[1]。
In Vivo	Malonomicin (30 mg/kg；腹腔注射，一次) 消除锥虫感染小鼠的感染情况，并且在每日 50 mg/kg 的剂量下没有显示出有害影响[2]。 Animal Model: Mice with Trypanosoma congolense infection[2] Dosage: 30 mg/kg Administration: Intraperitoneal injection; 30 mg/kg, once Result: Eliminated all trypanosomes from in the blood of infected mice.
References	[1]. Emilio L. Ghisalberti. Bioactive Tetramic Acid Metabolites. Studies in Natural Products Chemistry. Volume 28, Part I, 2003, Pages 109-163. [2]. Ottens Hendrik and Vos Cornelis. Preparation of an antibiotic for the treatment of trypanosomiasis. NL6701356. 1967.