Pefcalcitol

Names

[ Name ]:
Pefcalcitol

[Synonym ]:
2-{[(1S,3R,5Z,7E,9ξ,20S)-1,3-Dihydroxy-9,10-secopregna-5,7,10,16-tetraen-20-yl]oxy}-N-(2,2,3,3,3-pentafluoropropyl)acetamide
M5181
Pefcalcitol
2-(((1S,3R,5z,7E,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(19),16-tetraen-20-yl)oxy)-N-(2,2,3,3,3-pentafluoropropyl)acetamide
UNII-KT5224XSHW
Acetamide,2-((1S)-1-((3aS,7E,7as)-7-((2Z)-((3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene)ethylidene)-3a,4,5,6,7,7a-hexahydro-3a-methyl-1H-inden-3-yl)ethoxy)-N-(2,2,3,3,3-pentafluoropropyl)
Acetamide, 2-[(1S)-1-[(3aS,7E,7aS)-7-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]-3a,4,5,6,7,7a-hexahydro-3a-methyl-1H-inden-3-yl]ethoxy]-N-(2,2,3,3,3-pentafluoropropyl)-
Pefcalcitol [INN]

Biological Activity

[Description]:

Pefcalcitol is a new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Akira Takeiri, Kenji Tanaka. et al. Lack of Mutagenicity of SMD-502, a New Vitamin D3 Analog for Topical Application, in Skin and Liver of gpt delta Transgenic Mice and in GDL1 Cells. Genes and Encironment, Vol, 34, No. 3 pp. 107-114(2012)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
614.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₄F₅NO₄

[ Molecular Weight ]:
519.544

[ Flash Point ]:
325.1±31.5 °C

[ Exact Mass ]:
519.240784

[ PSA ]:
82.28000

[ LogP ]:
5.42

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.523

Related Compounds

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