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Flavokawain A

Names

[ CAS No. ]:
37951-13-6

[ Name ]:
Flavokawain A

[Synonym ]:
(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one
1OR CQ EO1 BV1U1R DO1 &&E Form
2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-, (2E)-
MFCD00017174
(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
2′-Hydroxy-4,4′,6′-trimethoxychalcone

Biological Activity

[Description]:

Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Zi X, et al. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res. 2005 Apr 15;65(8):3479-86.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
529.9±50.0 °C at 760 mmHg

[ Melting Point ]:
114℃

[ Molecular Formula ]:
C18H18O5

[ Molecular Weight ]:
314.332

[ Flash Point ]:
193.2±23.6 °C

[ Exact Mass ]:
314.115417

[ LogP ]:
3.96

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.600

Related Compounds